Andrew Pierce’s injury problems are back, and this time the University of Delaware football star’s season might be over.

Pierce, a junior running back from Cumberland Regional High School, sprained the medial collateral ligament in his right knee in Saturday’s loss.

“The good news is the long-term prognosis is he’ll be fine,” Delaware coach K.C. Keeler said in his weekly conference call Monday. “The bad news is the short-term prognosis is we’re not sure. We’re not sure if he’s going to miss a week or four weeks. There’s some sprained ligaments, and (doctors) are just not sure how he’s going to respond to everything. And at the position he plays … he’s cutting every play.

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“So I think he’s doubtful for this week (against Towson). I think there’s a better chance of maybe getting him for Richmond (on Nov. 10). But there’s a chance he might be done for the regular season.”

Pierce rushed for 2,934 yards in his first two seasons after walking on at Delaware.

But he got off to a slow start this season after being hampered by a hamstring injury in training camp. Keeler said Pierce was not himself until the Blue Hens’ third game this season, when he rushed for 101 yards in a 19-3 win over Bucknell on Sept. 15.

But less than three weeks later, Pierce tweaked the hamstring injury in practice. He carried just twice against Maine on Oct. 6 before leaving the game.

After a week off, Pierce came back with 141 yards and three touchdowns in a 47-24 win over Rhode Island.

Then, this past Saturday, he hurt his knee in a 31-26 loss to Old Dominion.

“Andrew came back and played great against Rhode Island, was having a pretty good day against Old Dominion, (but) Andrew unfortunately twisted his knee up,” Keeler said.

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