PHILADELPHIA — The Eagles’ offensive line could be undergoing yet another series of changes.

Center Dallas Reynolds did not practice Wednesday because of a sprained ankle suffered in Monday’s 30-22 loss to Carolina. If he can’t play Sunday at Dallas, left guard Evan Mathis will play center and Danny Watkins would rejoin the starting lineup at left guard.

“I’ve been taking snaps at center in practice all season, so it shouldn’t be much of an adjustment for me,” Mathis said. “If they need me to play center, I’ll play center. Whatever I can do to help the team.”

If Mathis plays center, it would be the sixth different offensive line combination the Eagles have used this season.

The unit has been battered by injuries since even before the season began. Left tackle Jason Peters (ruptured Achilles’ tendon), center Jason Kelce (torn knee ligaments) and right tackle Todd Herremans (dislocated bone in foot) are out for the rest of the year.

Tackles Demetress Bell and King Dunlap have played both left and right tackle. Right tackle Dennis Kelly started two games at right guard. Right guard Jake Scott wasn’t on the team three weeks ago. Watkins started the first six games at right guard before coming down with a mysterious ankle injury.

“You never want to change the offensive line,” Mathis said. “You always want it to stay the same. But it doesn’t always work that way.

Mathis said he played some center in college at the University of Alabama but has never played the position in a regular-season NFL game since entering the league with Carolina in 2005.

He said his last game experience was during a preseason game with Cincinnati in 2010.

“Dallas is a tremendous center and he’s done an amazing job,” Eagles quarterback Nick Foles said “But I know if Evan stepped in, he’d do a great job as well and he’d be ready to go. Evan’s an extremely smart guy and very talented. He’ll step up.”

Vick still sidelined

Quarterback Michael Vick did not practice again Wednesday and has yet to pass the team’s concussion tests.

Foles, who grew up in Austin, Texas, likely will make his third straight start on Sunday at Cowboys Stadium in Arlington, Texas.

The third-round draft pick has been inconsistent since taking over for Vick in the first half against Dallas on Nov. 11. He has completed 59-of-99 passes for 542 yards with three interceptions and one touchdown pass. He did not throw a TD pass in his first two starts.

“I feel like we’ve run the offense well and we’ve just got to eliminate mistakes,” Foles said. “I just want to keep progressing every day. Getting better every day on the practice field, working as hard as I can in the film room and everything and that’s all I can do.”

Roster moves upcoming

The Eagles’ active roster is missing two players after releasing defensive end Jason Babin and placing wide receiver DeSean Jackson on injured reserve Tuesday.

They are expected to promote two players from the practice squad. They have no defensive ends on the practice squad, so they may give linebacker Ryan Rau a shot to play special teams. Wide receivers B.J. Cunningham and Marvin McNutt are the candidates to fill Jackson’s roster spot.

Bumps and bruises

Defensive tackle Fletcher Cox (bruised tailbone), running back LeSean McCoy (concussion), running back Chris Polk (sprained toe), Reynolds (sprained ankle) and Vick (concussion) did not practice Wednesday. Dunlap (knee contusion) practiced on a limited basis.

Contact David Weinberg:

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