A study by researchers at the University of Pittsburgh has tied low vitamin D levels early in a woman's pregnancy to an increased risk of severe preeclampsia.

The study was able to examine a database of 44,500 women, picking out 717 that had developed preeclampsia. Severe preeclampsia sometimes requires induced labor and delivery.

Funded by the National Institutes of Health, the study will be published next month in the journal Epidemiology.

The women were part of the Collaborative Perinatal Project that ran from 1959 to 1965, the nation's largest-ever study of pregnant women. The women's blood was well preserved enough to be tested for vitamin D levels.

Researchers looked at vitamin D levels prior to 26 weeks gestation and examined whether there was any connection between low levels and preeclampsia, a pregnancy disorder signified by high blood pressure and elevated protein levels in urine. Complications of untreated preeclampsia can be dangerous, even fatal, to a woman and her baby.

While the researchers did not find a connection between vitamin D and mild preeclampsia, it did find a significant correlation between vitamin D and severe preeclampsia.

"Vitamin D status of the mothers was not related to preeclampsia when we looked at it overall, but when we separated it into two different subtypes, that's where we found a relationship," said Lisa Bodnar, an associate professor of epidemiology at Pitt's Graduate School of Public Health and lead author of the study.

No clear solution

The study does not necessarily suggest, however, that women can prevent preeclampsia by taking more vitamin D. It's possible that low vitamin D levels could be a side effect of the preeclampsia, which may actually start long before it shows up in a women's blood pressure or urine protein levels.

It could also be that the relationship in the data set, collected in the 1960s, no longer holds true today.

"Yes, we found this relationship, but we don't believe that women should run out and start taking more vitamin D supplements when they are planning a pregnancy or when they're pregnant," said Ms. Bodnar. "There's still a lot more research to be done."

Because severe pre-eclampsia is quite rare - occurring in roughly 5 out of 1,000 pregnancies - a very large sample would be needed to examine further the vitamin D link.

"It would take a lot of resources and a lot of people to answer the question right," said Bodnar.

Studies such as this one are hard to do because the data set required is so large, said Mark Caine, director of labor and delivery at West Penn Hospital, calling the Pitt research "a study that nobody else has really done."

He noted that re-searchers have been looking for causes of pre-eclampsia for some time, referring to a 10- to 15-year study on calcium that ultimately couldn't find a link to the disorder.

He also noted that vitamin D research is now in vogue, as researchers aim to link it to numerous diseases, both in and out of pregnancy.

"People have been looking at vitamin D levels for several different adverse pregnancy outcomes - intrauterine growth restriction, preterm labor, diabetes," he said. "The studies really still are all over the place."

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